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Science Articles about DNA from the NYT
My Genome, Myself: Seeking Clues in DNA
http://www.nytimes.com/2007/11/17/us/17dna.html
Series: The DNA Age By AMY HARMON
The exploration of the human genome has long been relegated to elite
scientists in research laboratories. But that is about to change. An
infant industry is capitalizing on the plunging cost of genetic testing
technology to offer any individual unprecedented and unmediated entree
to their own DNA.
For
as little as $1,000 and a saliva sample, customers will be able to
learn what is known so far about how the billions of bits in their
biological code shape who they are. Three companies have already
announced plans to market such services, one yesterday.
Offered the
chance to be among the early testers, I agreed, but not without
reservations. What if I learned I was likely to die young? Or that I
might have passed on a rogue gene to my daughter? And more
pragmatically, what if an insurance company or an employer used such
information against me in the future?
But three weeks later, I was
already somewhat addicted to the daily communion with my genes.
(Recurring note to self: was this addiction genetic?)
For example, my hands hurt the other day. So naturally, I checked my DNA.
Experts Advise a Grain of Salt With Mail-Order Genomes, at $1,000 a Pop
http://www.nytimes.com/2007/11/17/us/17genome.html
By NICHOLAS WADE
The
revolution in human genomics, still barely understood in the doctor's
office, is about to hit the street, at least for those able to pay
about $1,000 for a glance at their entire genome.
The Icelandic
company deCODE Genetics announced yesterday that it is now offering a
service called deCODEme, which will assess a person's genome for risk
of common diseases, bodily traits like hair and eye color, and
ancestral origins. Subscribers have to send in a scraping of cells from
inside the cheek and a check for $985.
Cancer Free at 33, but Weighing a Mastectomy
http://www.nytimes.com/2007/09/16/health/16gene.html
By AMY HARMON
CHICAGO Her latest mammogram was clean. But Deborah Lindner, 33, was tired of constantly looking for the lump.
Ever
since a DNA test had revealed her unusually high chance of developing
breast cancer, Ms. Lindner had agonized over whether to have a
mastectomy, a procedure that would reduce her risk by 90 percent.
As Breeders Test DNA, Dogs Become Guinea Pigs
http://www.nytimes.com/2007/06/12/science/12dog.html
By AMY HARMON
FORT MOTT STATE PARK, N.J. When mutant, muscle-bound puppies started
showing up in litters of champion racing whippets, the breeders of the
normally sleek dogs invited scientists to take DNA samples at race
meets here and across the country. They hoped to find a genetic cause
for the condition and a way to purge it from the breed.
It
worked. Bully whippets, as the heavyset dogs are known, turn out to
have a genetic mutation that enhances muscle development. And breeders
may not want to eliminate the bully gene after all. The scientists
found that the same mutation that pumps up some whippets makes others
among the fastest dogs on the track.
With a DNA screening test on
the way, Were going to keep the speed and lose the bullies, Helena
James, a whippet breeder in Vancouver, British Columbia, said.
Prenatal Test Puts Down Syndrome in Hard Focus
http://www.nytimes.com/2007/05/09/us/09down.html
By AMY HARMON
DETROIT Sarah Itoh, a self-described almost-eleven-and-a-half, betrayed
no trace of nervousness as she told a roomful of genetic counselors and
obstetricians about herself one recent afternoon.
She
likes to read, she said. Math used to be hard, but it is getting
easier. She plays clarinet in her school band. She is a junior girl
scout and an aunt, and she likes to organize, so he
room is very clean. Last year, she won three medals in the Special Olympics.
I am so lucky I get to do so many things, she concluded. I just want you to know, even though I have Down syndrome, it is O.K.
Stalking Strangers' DNA to Fill in the Family Tree
http://www.nytimes.com/2007/04/02/us/02dna.html
By AMY HARMON
They swab the cheeks of strangers and pluck hairs from corpses. They
travel hundreds of miles to entice their suspects with an old
photograph, or sometimes a free drink. Cooperation is preferred, but
not necessarily required to achieve their ends.
If
the amateur genealogists of the DNA era bear a certain resemblance to
members of a CSI team, they make no apologies. Prompted by the advent
of inexpensive genetic testing, they are tracing their family trees
with a vengeance heretofore unknown.
People who realize the
potential of DNA, said Katherine Borges, a co-founder of the
International Society of Genetic Genealogy, will go to great lengths to
get it.
Facing Life With a Lethal Gene
http://www.nytimes.com/2007/03/18/health/18huntington.html
Ms.
Moser was 23. It had taken her months to convince the clinic at
NewYork-Presbyterian Hospital/Columbia University Medical Center in
Manhattan that she wanted, at such a young age, to find out whether she
carried the gene for Huntingtons disease.
Huntingtons, the incurable
brain disorder that possessed her grandfathers body and ravaged his
mind for three decades, typically strikes in middle age. But most young
adults who know the disease runs in their family have avoided the DNA
test that can tell whether they will get it, preferring the torture and
hope of not knowing.
Ms. Moser is part of a vanguard of people at
risk for Huntingtons who are choosing to learn early what their future
holds. Facing their genetic heritage, they say, will help them decide
how to live their lives.
DNA Gatherers Hit Snag: Tribes Don't Trust Them
http://www.nytimes.com/2006/12/10/us/10dna.html
By AMY HARMON Correction Appended
SOUTH
NAKNEK, Alaska The National Geographic Societys multimillion-dollar
research project to collect DNA from indigenous groups around the world
in the hopes of reconstructing humanitys ancient migrations has come to
a standstill on its home turf in North America.
Billed as the moon
shot of anthropology, the Genographic Project intends to collect
100,000 indigenous DNA samples. But for four months, the project has
been on hold here as it scrambles to address questions raised by a
group that oversees research involving Alaska natives.
At issue is
whether scientists who need DNA from aboriginal populations to fashion
a window on the past are underselling the risks to present-day donors.
Geographic origin stories told by DNA can clash with long-held beliefs,
threatening a world view some indigenous leaders see as vital to
preserving their culture.
They argue that genetic ancestry
information could also jeopardize land rights and other benefits that
are based on the notion that their people have lived in a place since
the beginning of time.
Couples Cull Embryos to Halt Heritage of Cancer
http://www.nytimes.com/2006/09/03/health/03gene.web.html
By AMY HARMON
As Chad Kingsbury watches his daughter playing in the sandbox behind
their suburban Chicago house, the thought that has flashed through his
mind a million times in her two years of life comes again: Chloe will
never be sick.
Not,
at least, with the inherited form of colon cancer that has devastated
his family, killing his mother, her father and her two brothers, and
that he too may face because of a genetic mutation that makes him
unusually susceptible.
By subjecting Chloe to a genetic test when she was an eight-cell embryo
in a petri dish, Mr. Kingsbury and his wife, Colby, were able to
determine that she did not harbor the defective gene. That was the
reason they selected her, from among the other embryos they had
conceived through elective in vitro fertilization, to implant in her
mothers uterus.
That Wild Streak? Maybe It Runs in the Family
http://www.nytimes.com/2006/06/15/health/15gene.html
By AMY HARMON
Jason Dallas used to think of his daredevil streak a love of
backcountry skiing, mountain bikes and fast vehicles as "a personality
thing."
Then
he heard that scientists at the Fred Hutchinson Cancer Research Center
in Seattle had linked risk-taking behavior in mice to a gene. Those
without it pranced unprotected along a steel beam instead of huddling
in safety like the other mice.
Now Mr. Dallas, a chef in Seattle, is convinced he has a genetic
predisposition for risk-taking, a conclusion the researchers say is not
unwarranted, since they believe similar variations in human genes can
explain why people perceive danger differently.
"It's in your blood," Mr. Dallas said. "You hear people say that kind of thing, but now you know it really is."
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