In the basement of a university in Lausanne, Switzerland sit four black boxes, each about the size of a refrigerator, and filled with 2,000 IBM microchips stacked in repeating rows. Together they form the processing core of a machine that can handle 22.8 trillion operations per second. It contains no moving parts and is eerily silent. When the computer is turned on, the only thing you can hear is the continuous sigh of the massive air conditioner. This is Blue Brain.

The name of the supercomputer is literal: Each of its microchips has been programmed to act just like a real neuron in a real brain. The behavior of the computer replicates, with shocking precision, the cellular events unfolding inside a mind. "This is the first model of the brain that has been built from the bottom-up," says Henry Markram, a neuroscientist at Ecole Polytechnique Fédérale de Lausanne (EPFL) and the director of the Blue Brain project. "There are lots of models out there, but this is the only one that is totally biologically accurate. We began with the most basic facts about the brain and just worked from there."

Before the Blue Brain project launched, Markram had likened it to the Human Genome Project, a comparison that some found ridiculous and others dismissed as mere self-promotion. When he launched the project in the summer of 2005, as a joint venture with IBM, there was still no shortage of skepticism. Scientists criticized the project as an expensive pipedream, a blatant waste of money and talent. Neuroscience didn't need a supercomputer, they argued; it needed more molecular biologists. Terry Sejnowski, an eminent computational neuroscientist at the Salk Institute, declared that Blue Brain was "bound to fail," for the mind remained too mysterious to model. But Markram's attitude was very different. "I wanted to model the brain because we didn't understand it," he says. "The best way to figure out how something works is to try to build it from scratch."

The Blue Brain project is now at a crucial juncture. The first phase of the project—"the feasibility phase"—is coming to a close. The skeptics, for the most part, have been proven wrong. It took less than two years for the Blue Brain supercomputer to accurately simulate a neocortical column, which is a tiny slice of brain containing approximately 10,000 neurons, with about 30 million synaptic connections between them. "The column has been built and it runs," Markram says. "Now we just have to scale it up." Blue Brain scientists are confident that, at some point in the next few years, they will be able to start simulating an entire brain. "If we build this brain right, it will do everything," Markram says. I ask him if that includes selfconsciousness: Is it really possible to put a ghost into a machine? "When I say everything, I mean everything," he says, and a mischievous smile spreads across his face.

Henry Markram is tall and slim. He wears jeans and tailored shirts. He has an aquiline nose and a lustrous mop of dirty blond hair that he likes to run his hands through when contemplating a difficult problem. He has a talent for speaking in eloquent soundbites, so that the most grandiose conjectures ("In ten years, this computer will be talking to us.") are tossed off with a casual air. If it weren't for his bloodshot, blue eyes—"I don't sleep much," he admits—Markram could pass for a European playboy.